BioXclude Membrane

$49.00 - $219.00
(1 review)
Current Stock:


BioXclude is a minimally manipulated allograft amnion chorion tissue for use as a wound covering in dental surgery. Since its introduction in 2010, Snoasis Medical has distributed over 70,000 grafts of BioXclude. This allograft represents a paradigm shift in regenerative technology. Its unique physical and biological properties provide the benefits of a growth factor and an occlusive barrier.

Product Description

Tissue cross section.

The tissue used in BioXclude is obtained from consenting mothers who donate their placentas after elective caesarian section delivery. The amnion chorion tissue is processed using Purion®, a patented, tissue processing technology designed to cleanse and maintain the delicate structures of the tissue. Following processing and dehydration, the allografts are packaged and terminally sterilized (SAL 10-6). This processing methodology allows for retention of the biological factors found in native amnion chorion tissue.

Growth Factor Properties

BioXclude has been shown to contain over 250 biological factors, extracellular matrix (ECM) proteins, cytokines, interleukins, and tissue inhibitors of metalloproteinase (TIMP), known to play a role in wound healing and reducing inflammation1–4. In vitro, in vivo, and clinical research demonstrate the following benefits:1-3,5-9

    • Rapid wound closure when left exposed
    • Cellular occlusive with rapid sealing of protected space
    • Hastens flap reattachment
    • Allows for rapid vascular growth
    • Shown to recruit mesenchymal stem cells
    • Suppresses inflammation

Occlusive Barrier Properties

The physical properties of BioXclude allow clinicians to avoid many of the drawbacks associated with traditional collagen and synthetic membranes, which can help simplify the procedure, allow for less invasive surgery, and reduced chair time.5,7,10

A processed, sterilized graft of BioXclude.

  • No trimming required
  • Extremely thin; does not add meaningful bulk to the site
  • Lacks rigidity and is self-adherent with excellent adaption
  • Can be placed UP or DOWN and fold onto itself
  • Can be placed over exposed roots and grafted implants
  • May be placed over or under other membranes, meshes or palatal tissue


The unique biologic and physical properties of amnion and amnion chorion (BioXclude) allograft allow it to be used as a wound covering for a multitude of dental implant / periodontal / oral maxillofacial applications which include5, 9, 11-17:

  • Socket Preservation
  • Implants
  • Peri-Implantitis
  • Periodontal
  • Ridge Augmentations
  • Sinus/Flap Perforations
  • Oral Wounds
  • Growth Factor
Site PresentationA
BioXclude left exposed over #20 site grafted with Maxxeus 70/30.
Excellent healing at 9 days with granulation tissue covering exposed portion of BioXclude.
Healing at 7 weeks with healthy gingival tissue covering the site.
At 6 months, implant is surrounded with a wide zone of attached keratinized tissue.
ImplantB 84 year old male with large buccal defect on #29; implant placed.
Once adapted over grafted implant, BioXclude adds minimal bulk.
Great contour of the gingiva at 4 months.
Reentry at 4 months reveals excellent new bone formation.
PeridontalA Smoker; #18D 11mm PD, #19B 8mm PD (grade 2 furc), #19M 7mm PD.
BioXclude placed over exposed roots and defects grafted with Maxxeus 70/30.
At 12 months, the gingival margin is maintained with a small gain in root coverage.
30 month radiograph shows defect resolution; #18D 4mm PD, #19B 3mm PD, #19M 3mm.

Sizing, Storage and Ordering

Using a larger piece makes placement much easier as it can fold over itself and/or multiple pieces overlap one another. The allograft also contains biological factors to aid healing. For these reasons, clinicians are encouraged to order larger sizes of BioXclude than they would when purchasing a traditional barrier membrane. BioXclude contains biological factors to aid healing. For this reason, and because it is thin, adaptable and excess material can be folded onto itself, clinicians are encouraged to use the entire piece, or in some cases, a bigger piece depending on the procedure. BioXclude is for single use only and is available in six sizes.

8mm x 8mm
12mm x 12mm
10mm x 20mm
15mm x 20mm
15mm x 25mm
20mm x 30mm


  • 5
    Great Product and Great Customer Service

    Posted by Unknown on Mar 16th 2021

    Handling of the membrane is a bit tricky but it is a great product for GBR procedures as a secondary membrane if primary closure is not possible. I have used it by itself as socket preservation and cases with missing buccal plate and it does work well. Great customer service and fast shipment. Thank you.